What is meant by OTC medicine (without doctor prescription)? OTC (over-the-counter): Available without a prescription. OTC drugs are available without a prescription, simply "over the counter." OTC drugs are in contrast to prescription drugs that require a doctor's order.What are examples of over the counter drugs. Popular examples include pain relievers like acetaminophen (Tylenol) and ibuprofen (Advil, Motrin), cough suppressants such as dextromethorphan (Robitussin) and antihistamines like loratadine (Claritin 24H) and mens health (generic Viagra, Levitra, Cialis). These drugs are usually located on shelves in pharmacies, grocery stores, and even in gas stations.